项目名称： 光合细菌絮凝与收集相关问题的动力学建模与理论和数值研究

项目编号： No.11471034

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 马万彪

作者单位： 北京科技大学

项目金额： 65万元

中文摘要： 随着生物科学的迅速发展，发现一些重要的光合菌类，如小球藻与沼泽红假单胞均等，由于富含丰富的蛋白质、高度不饱和脂肪酸、类胡萝卜素、叶黄素和多种维生素等, 以及具有增强人体免疫的功能作用等，在人类健康、医药卫生、环境工程、生化工程等领域具有广泛的应用价值。另一方面，由于厌氧光照培养获得的光合细菌细胞浓度比较低, 因此，如何高效收集培养物中的光合细菌细胞是限制其应用的主要瓶颈之一。 本研究项目主要采用动力学方法研究光合细菌的培养和增长机制、絮凝剂的消耗与菌类絮凝效果的综合评价等问题，这对沼泽红假单胞菌细胞等光合细菌的收集与产业化提供必要的理论依据。主要内容包括三部分：(1) 沼泽红假单胞菌的絮凝与收集相关问题的动力学建模与理论和数值分析；(2) 沼泽红假单胞菌的异养培养与番茄红素生产的优化控制策略问题；(3) 沼泽红假单胞菌与小球藻共培养相关问题的动力学建模与理论和数值分析。

中文关键词： 光合细菌；降解；絮凝剂；动力学模型；稳定性

英文摘要： With the rapid development of life sciences, studies have found some important photosynthetic fungi, such as Chlorella and Rhodopseudomonas palustris. These photosynthetic fungi are rich in protein, highly unsaturated fatty acids, carotenoids, lutein and various vitamins, and they can enhance human immunity, and hence have a wide range of valuable application in health, medicine, environmental engineering, biochemical engineering and other fields. Therefore, studying the dynamics related to the mechanisms of flocculation and extraction methods of the photosynthetic bacteria has an important application value. On the other hand, since the density of photosynthetic bacteria by the method of anaerobic light culture is relatively low, and therefore, to find efficient methods to collect photosynthetic bacteria becomes very important in applications. This research project is mainly based on dynamic method to study growth mechanisms of photosynthetic bacteria and evaluation of the effect of flocculants. This provides necessary theoretical basis for collection and application of photosynthetic bacteria. This research project contains includes three parts. (1) Dynamic models describing flocculation and collection of photosynthetic bacteria, as well as theoretical and numerical analysis of the models. (2) Optimal control strategy in culture of photosynthetic bacteria and production of lycopene. (3) Dynamic models describing co-culture of Chlorella and photosynthetic bacteria , as well as theoretical and numerical analysis.

英文关键词： Bacteria;Degradation;Flocculation;Dynamic model;Stability