项目名称： Egr-2在Th17细胞分化中的作用及其机制研究

项目编号： No.30870516

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 电工技术

项目作者： 朱波

作者单位： 中国人民解放军第三军医大学

项目金额： 34万元

中文摘要： 本课题组在国家自然科学基金项目资助下，从2008年开始主要围绕Th17在肿瘤组织表达及其对预后的影响及Egr-2对肿瘤组织中Th17的表达调控机制开展研究：在Th17在肿瘤组织表达方面，主要围绕IL-17这一重要的炎症因子研究其对非小细胞肺癌、结直肠癌预后及淋巴管、血管生成的影响，同时阐明了深入机制；在Th17表达调控方面，主要研究了Egr-2在肿瘤浸润性Th17分化调控中的机制问题。通过本项目的研究，在Lung Cancer， Cancer Science， BBRC等国际专业期刊发表与本项目相关的SCI论文5篇，参加国际会议交流2次，申请者朱波教授于2011年获得中国青年科技奖，并作为项目主要完成人申报成功中华科技一等奖1项，培养博士研究生2名，硕士研究生2名。

中文关键词： Th17;Egr-2;非小细胞肺癌;大肠癌

英文摘要： Under support of project by National Nature Science Foundation of China, our group focus on the expression of Th17 in non-small-cell lung carcinoma, colorectal carcinoma and it's roles on the progress of above referred carcinoma. In the present project, we found there is correlation between Th17 expression and prognosis in non-small cell lung carcinoma and colorectal carcinoma. Furthermore, we found the effect of Th17 on the prognosis of patients is due to the role of IL-17 in angiogenesis and lymphogenesis. We also elucidated the underlying mechanisms of Egr-2 in tumor-infiltration Th17 differentiation. Under support of this project, we have published five SCI cited papers and attend international conference two times. Professor Zhu was awarded "Chinese Youth Scientific Award" and "Chinese Medical Scientific Award ", also two Ph.D students and two postgradute students finished their degrees.

英文关键词： Th17; Egr-2; non-small-cell lung carcinoma; colorectal carcinoma