We show that multi-invariants provide necessary and sufficient criteria for full separability in finite-dimensional multipartite systems. For tripartite three-qubit states, the third-order negativity gives an exact criterion for full separability for both pure and mixed states. We then extend the framework to four-qubit pure states, whose full characterization requires eighteen independent real parameters. We identify eighteen independent entanglement measures, consisting of six bipartite, eight tripartite, and four quadripartite measures, with the third-order negativity serving as a key separability criterion. Finally, we generalize the construction to multipartite qudit systems and discuss an application to conformal field theory.

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