In recent years, 2D-to-3D pose uplifting in monocular 3D Human Pose Estimation (HPE) has attracted widespread research interest. GNN-based methods and Transformer-based methods have become mainstream architectures due to their advanced spatial and temporal feature learning capacities. However, existing approaches typically construct joint-wise and frame-wise attention alignments in spatial and temporal domains, resulting in dense connections that introduce considerable local redundancy and computational overhead. In this paper, we take a global approach to exploit spatio-temporal information and realise efficient 3D HPE with a concise Graph and Skipped Transformer architecture. Specifically, in Spatial Encoding stage, coarse-grained body parts are deployed to construct Spatial Graph Network with a fully data-driven adaptive topology, ensuring model flexibility and generalizability across various poses. In Temporal Encoding and Decoding stages, a simple yet effective Skipped Transformer is proposed to capture long-range temporal dependencies and implement hierarchical feature aggregation. A straightforward Data Rolling strategy is also developed to introduce dynamic information into 2D pose sequence. Extensive experiments are conducted on Human3.6M, MPI-INF-3DHP and Human-Eva benchmarks. G-SFormer series methods achieve superior performances compared with previous state-of-the-arts with only around ten percent of parameters and significantly reduced computational complexity. Additionally, G-SFormer also exhibits outstanding robustness to inaccuracies in detected 2D poses.

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