We consider the problem of estimating the expectation of a function (observable) with respect to a high-dimensional probability distribution, under the assumption that a low-dimensional collective variable map captures all the directions of slow mixing for the distribution. More precisely, under the assumption that the fibers of the collective variable map satisfy a log-Sobolev inequality, we establish non-asymptotic relative-error guarantees for this problem using the eigenvector method for umbrella sampling (EMUS). Our analysis applies to both log-Lipschitz observables and indicator of convex sets, and gives complexity bounds that are polynomial in regularity parameters and inverse relative accuracy, and exponential in the dimension of the collective variable space. As a relative error guarantee, our bounds apply to rare event estimation. We consider Gaussian biasing windows defined on a low-dimensional collective variable space and analyze a modified sparse matrix version of EMUS. The bounds quantify the effect of the map through mixing of the conditional distribution and fluctuation of the observable along the fibers.

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