In this paper, we study Nyström subsampling for vector-valued regression in vector-valued reproducing kernel Hilbert spaces. Standard kernel methods often suffer from prohibitive computational costs due to the construction and inversion of large kernel matrices, which limits their scalability to large datasets. To overcome this bottleneck, we propose an efficient operator learning algorithm based on Nyström subsampling that accommodates functional outputs. Under general source conditions characterized by index functions-extending beyond the classical Hölder-type and operator-monotone frameworks-we establish minimax-optimal convergence rates for the proposed estimator. As an application of the proposed framework, we consider function denoising problems. Unlike classical denoising methods, which are typically tailored to specific signal representations or noise models, our approach formulates denoising within a general operator learning framework. Numerical experiments on signal denoising, real-time audio denoising, image denoising, inverse Radon transform reconstruction, and energy-efficiency prediction confirm that the proposed method achieves performance comparable to full kernel methods while substantially reducing computational cost.

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