Hybrid classical-quantum computing requires frequent data exchange between classical processors and quantum control hardware. However, existing superconducting quantum control systems are commonly connected through loosely coupled interfaces such as Ethernet, resulting in high communication latency and limited task throughput. To address this issue, we present HI-HCQC, an RFSoC-based hardware interface for tightly coupled hybrid classical-quantum computing. HI-HCQC integrates high-speed RF-DACs, RF-ADCs, programmable logic, embedded processors, clock synchronization circuits, and a PCIe Gen3 x8 interface, enabling direct microwave pulse synthesis, qubit readout, and high-throughput data transfer between host servers and quantum measurement-control units. Experimental results show that HI-HCQC supports six control channels and one multiplexed readout channel, achieves stable microwave generation and acquisition, and successfully performs qubit spectroscopy, Rabi oscillation, T1 measurement, single-shot readout, randomized benchmarking, and CZ-gate characterization. Compared with a conventional control system, HI-HCQC reduces end-to-end execution latency for representative quantum gate and circuit tasks and significantly improves task throughput. These results demonstrate that PCIe-coupled RFSoC control hardware provides a practical foundation for scalable and efficient hybrid classical-quantum computing systems.

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