The post-ChatGPT surge has rapidly reframed IS research and practice. As organizations and society grapple with GenAI adoption, a body of secondary studies and research agendas has emerged to synthesize early evidence and chart directions for future inquiry. This study reviews secondary and roadmap papers to synthesize the state of knowledge on GenAI's benefits and challenges in IS, and to identify future research directions. We performed a systematic search across Scopus, WoS, and eAIS for publications from 2023 onwards. Following a rigorous, multi-stage screening process, we selected a final set of 28 papers for analysis using bibliometric mapping and thematic analysis. We also conducted a quality assessment of all sources to gauge confidence in each source's contribution to the findings. GenAI offers transformative potential to drive productivity, accelerate innovation, personalize services, and democratize access to expertise. However, its adoption is constrained by interrelated challenges: technical unreliability, societal-ethical risks, and a governance vacuum. Interpreted through a socio-technical lens, our findings reveal a persistent misalignment between GenAI's fast-evolving technical subsystem and the slower-adapting social subsystem, positioning IS research as critical for achieving joint optimization. To bridge this gap, we propose a research agenda that reorients IS scholarship from analyzing impacts toward actively shaping the co-evolution of technical capabilities with organizational routines, societal values, and regulatory institutions: emphasizing hybrid human-AI ensembles, situated validation, design principles for probabilistic systems, and adaptive governance. For practitioners and policymakers, responsible adoption requires balancing automation with human augmentation alongside transparent governance and adaptive regulations to ensure broadly shared benefits.
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