Satellite mega-constellations in Low Earth Orbit (LEO) are becoming an important part of next-generation non-terrestrial networks, but their operation remains challenging because of fast network topology variation, intermittent inter-satellite links, hardware disturbances, and strict Size, Weight, and Power (SWaP) constraints. Existing approaches based on Digital Twin (DT), Digital Twin Network (DTN), Software-Defined Networking (SDN), and Open Radio Access Network (O-RAN) provide useful building blocks for intelligent satellite networking, but they do not fully support real-time, predictive, and platform-aware network operation. In this paper, we propose a Digital Twin Satellite Network (DTSN) framework as a closed-loop architecture for reliable and intelligent management of LEO satellite constellations. The proposed framework connects the physical satellite network with a synchronized virtual twin and combines real-time telemetry, Integrated Sensing and Communication (ISAC), predictive intelligence, and resilience-oriented control. To validate the concept, we develop a constellation-scale cross-domain co-simulation using the NASA 42 spacecraft simulator and a Python-based DT bridge for a LEO constellation. The DT continuously ingests physical telemetry to manage a multi-domain threat environment, encompassing kinematic drift, hardware failures, and adversarial jamming over a 600-second flight window. By leveraging a predictive lookahead mechanism and an exponential sensor recovery model, the framework successfully isolates compromised nodes and triggers proactive network reconfiguration, thereby ensuring uninterrupted service and dynamic network resilience. These results show the potential of DTSN to support predictive and resilience-oriented satellite network operations.

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