The year 2023 marked a significant surge in the exploration of applying large language model (LLM) chatbots, notably ChatGPT, across various disciplines. We surveyed the applications of ChatGPT in various sectors of bioinformatics and biomedical informatics throughout the year, covering omics, genetics, biomedical text mining, drug discovery, biomedical image understanding, bioinformatics programming, and bioinformatics education. Our survey delineates the current strengths and limitations of this chatbot in bioinformatics and offers insights into potential avenues for future development.

翻译：摘要：2023年，探索大型语言模型聊天机器人（尤其是ChatGPT）在各学科应用的研究显著激增。我们系统调研了该年度ChatGPT在生物信息学与生物医学信息学各领域的应用，涵盖组学、遗传学、生物医学文本挖掘、药物发现、生物医学图像理解、生物信息学编程及生物信息学教育。本综述揭示了该聊天机器人在生物信息学领域的当前优势与局限，并展望了未来潜在的发展方向。