We propose a framework for planning in unknown dynamic environments with probabilistic safety guarantees using conformal prediction. Particularly, we design a model predictive controller (MPC) that uses i) trajectory predictions of the dynamic environment, and ii) prediction regions quantifying the uncertainty of the predictions. To obtain prediction regions, we use conformal prediction, a statistical tool for uncertainty quantification, that requires availability of offline trajectory data - a reasonable assumption in many applications such as autonomous driving. The prediction regions are valid, i.e., they hold with a user-defined probability, so that the MPC is provably safe. We illustrate the results in the self-driving car simulator CARLA at a pedestrian-filled intersection. The strength of our approach is compatibility with state of the art trajectory predictors, e.g., RNNs and LSTMs, while making no assumptions on the underlying trajectory-generating distribution. To the best of our knowledge, these are the first results that provide valid safety guarantees in such a setting.

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