We present BioNetFlux, an open-source Python framework for the numerical simulation of coupled systems of partial differential equations (PDEs) on one-dimensional multi-arc networks by the Hybridized Discontinuous Galerkin method. Its design targets biological transport phenomena on graph-like geometries that arise naturally in microfluidic organ-on-chip (OoC) devices, vascular networks, and in-vitro cell-migration assays.

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