The Quantum Fisher Information (QFI) metric governs a fundamental duality: it quantifies both how precisely a parameter can be estimated (metrology) and how distinguishable two quantum states are (privacy). We exploit this duality to establish a geometry-aware framework for quantum differential privacy (DP) that replaces isotropic depolarizing noise with direction-dependent noise aligned to the QFI eigenstructure of the quantum embedding. We prove six principal theorems: (1) the minimax-optimal mechanism concentrates the noise budget in the dominant QFI eigenmode, achieving $\varepsilon = (Δ^2/2)λ_{\max}(1-cγ)$ with $O(d/λ_{\max})$ advantage; (2) mixed-state QFI decomposition reveals that dephasing in the adversary's basis $\textit{increases}$ accessible information, while misaligned-basis dephasing provides constructive privacy amplification from hardware noise; (3) a tight privacy $-$ utility uncertainty relation $\varepsilon \cdot (1 - F) \ge \frac{Δ^2}{2}\frac{\operatorname{Tr}(F)}{d}$; (4) adaptive QFI estimation converging at $O(1/\sqrt{n})$ yields $1.92\times$ tighter bounds; (5) QFI-aligned composition saturates at $O(1)$ versus $O(k)$ for standard composition; and (6) hardware noise can be harnessed for privacy amplification. Adversarial vulnerabilities, Wasserstein guarantees, subspace projection, and a zero-knowledge audit protocol follow as corollaries. Results are validated on Qiskit Aer GPU simulations, IBM Quantum hardware (ibm_fez, 156 qubits), and against classical DP baselines, achieving equivalent utility at $\varepsilon \approx 0.001$ versus $\varepsilon \approx 4800$ for classical DP.

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