Intensity Modulated Radiation Therapy is an effective cancer treatment. Models based on the Generalized Equivalent Uniform Dose (gEUD) provide radiation plans with excellent planning target volume coverage and low radiation for organs at risk. However, manual adjustment of the parameters involved in gEUD is required to ensure that the plans meet patient-specific physical restrictions. This paper proposes a radiotherapy planning methodology based on bi-level optimization. We evaluated the proposed scheme in a real patient and compared the resulting irradiation plans with those prepared by clinical planners in hospital devices. The results in terms of efficiency and effectiveness are promising.

翻译：[摘要] 调强放射治疗是一种有效的癌症治疗方法。基于广义等效均匀剂量（gEUD）的模型能够提供具有优异靶区覆盖率和低危及器官受量的放疗计划。然而，为确保计划满足患者特定的物理约束条件，需人工调整gEUD中涉及的参数。本文提出一种基于双层优化的放疗计划方法。我们在真实患者数据上评估了所提方案，并将生成的照射计划与临床规划师在医院设备上制定的计划进行了比较。在效率与有效性方面的初步结果令人满意。