We implement full, three-dimensional constrained mixture theory for vascular growth and remodeling into a finite element fluid-structure interaction (FSI) solver. The resulting "fluid-solid-growth" (FSG) solver allows long term, patient-specific predictions of changing hemodynamics, vessel wall morphology, tissue composition, and material properties. This extension from short term (FSI) to long term (FSG) simulations increases clinical relevance by enabling mechanobioloigcally-dependent studies of disease progression in complex domains.

翻译：我们将完整的三维约束混合理论用于血管生长与重塑，并将其集成到有限元流固耦合（FSI）求解器中。由此产生的“流体-固体-生长”（FSG）求解器能够实现长期、患者特异性的血流动力学变化、血管壁形态、组织成分及材料特性的预测。这一从短期（FSI）到长期（FSG）模拟的扩展，通过支持复杂区域中疾病进展的力学生物学依赖性研究，提升了临床相关性。