Facial biometric recognition systems currently face compound threats intertwining generative AI and high-fidelity physical spoofing. Existing defenses suffer from systemic bottlenecks, including poor generalization, non-auditable reasoning, and reliance on massive, low-quality datasets. To address these challenges, we propose Multimodal Large Language Models (MFAD) for face anti-spoofing detection, an explainable reasoning system for Unified Face Anti-Spoofing Detection (UFAD), accompanied by a semantic-level annotation benchmark. Unlike methods relying on external tools or coarse alignment, MFAD activates the intrinsic reasoning capabilities of Multimodal Large Language Models (MLLMs) via a fine-grained pixel-semantic anchoring mechanism. This eliminates localization hallucinations and ensures auditable reasoning paths. We introduce a cross-attack semantic-level unified annotation paradigm: by annotating only 1,000 precise masks per attack category, we generate reasoning evidence chains strictly corresponding to spoofed regions. Supervised fine-tuning on the Qwen-VL foundation model demonstrates that, using limited high-quality samples, the system achieves a 40-50% relative reduction in in-domain ACER and restricts cross-domain performance degradation to within 11.62%/5.23%, significantly outperforming existing frameworks. Furthermore, under white-box adversarial attacks, detection accuracy drops by only 3.2%, validating the robustness of semantic anchoring compared to models trained on massive short-text data. Domain practitioners rated the evidence reliability of reasoning paths at 4.57/5, with inference latency satisfying real-time deployment requirements. These results confirm that a few-shot, high-quality semantic annotation paradigm is effective for building trustworthy, explainable, and cost-efficient UFAD systems.

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