Estimands can help to clarify the research questions being addressed in randomised trials. Because the choice of estimand can affect how relevant trial results are to patients and other stakeholders, such as clinicians or policymakers, it is important for them to be involved in these decisions. However, there are barriers to having these conversations. For instance, discussions around how intercurrent events should be addressed in the estimand definition typically involve complex concepts as well as technical language. We three tools to facilitate conversations between researchers and patients and other stakeholders about the choice of estimand and intercurrent event strategy: (i) a video explaining the concept of an estimand and the five different ways that intercurrent events can be incorporated into the estimand definition; (ii) an infographic outlining these five strategies; and (iii) an editable PowerPoint slide which can be completed with trial-specific details to facilitate conversations around choice of estimand for a particular trial. These resources can help to start conversations between the trial team and patients and other stakeholders about the best choice of estimand and intercurrent event strategies for a randomised trial.

翻译：估计目标有助于阐明随机试验所探讨的研究问题。由于估计目标的选择会影响试验结果对患者及其他利益相关者（如临床医生或政策制定者）的相关性，因此让他们参与这些决策至关重要。然而，开展此类对话存在障碍。例如，围绕如何在估计目标定义中处理中间事件的讨论通常涉及复杂概念和技术术语。我们提出了三种工具，以促进研究人员与患者及其他利益相关者之间就估计目标选择及中间事件策略进行对话：（i）一段解释估计目标概念以及将中间事件纳入估计目标定义的五种不同方式的视频；（ii）概述这五种策略的信息图；（iii）一份可编辑的 PowerPoint 幻灯片，可填入特定试验的详细信息，以促进围绕特定试验估计目标选择的讨论。这些资源有助于试验团队与患者及其他利益相关者就随机试验中估计目标及中间事件策略的最佳选择展开对话。