Integrated Sensing and Communication (ISAC) systems rely on accurate Direction-of-Arrival (DoA) estimation for effective beamforming and spectral-efficiency enhancement. While numerous classical and deep-learning-based DoA estimation methods have been reported in the literature, their suitability for real-time ISAC operation remains insufficiently understood because practical deployment requires consideration of both estimation accuracy and computational latency. This paper presents a unified evaluation framework for systematically comparing classical and learning-based DoA estimators within an ISAC beamforming pipeline. Representative classical and learning-based DoA estimators, together with an ensemble architecture, are integrated with Singular Value Decomposition (SVD)-based beamforming and evaluated under identical operating conditions. The impact of DoA estimation accuracy, inference latency, beamforming-weight generation time, and resulting effective spectral efficiency is investigated. Results show that different estimators occupy distinct operating points in the accuracy-latency-performance design space. Although learning-based approaches substantially reduce estimation time compared with MUSIC, the overall processing latency increasingly becomes dominated by the computational cost of SVD-based beamforming. Among the evaluated methods, the Regression Convolutional Neural Network (RCNN) exhibits a favorable balance between estimation accuracy, computational efficiency, and beamforming performance, making it a promising candidate for real-time ISAC deployment. The findings further suggest that future low-latency ISAC systems may benefit from beamforming strategies that reduce or avoid computationally intensive SVD-based beamforming-weight generation.

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