Treewidth is a fundamental graph invariant that quantifies how tree-like a given graph is. It is extensively used with dynamic programming to design fixed-parameter tractable algorithms for many NP-hard graph combinatorial optimization problems. However, despite broad theoretical applicability, treewidth dynamic programming (TDP) does not scale in practice beyond graphs with very small treewidth. Rather than applying TDP as a standalone technique, in this paper, we demonstrate that TDP can serve as a broadly applicable enhancer for a wide range of graph combinatorial optimization algorithms. Our framework leverages the concept of treewidth modulators, which refer to vertex sets whose removal significantly reduces the treewidth. We further propose an empirically efficient procedure for generating such treewidth modulators. To enhance an algorithm $\textit{A}$, we use $\textit{A}$ to heuristically make decisions on the modulators vertices, after which the remaining decisions outside the treewidth modulators become scalable for TDP. To demonstrate the general applicability of our proposed framework. We experimented with three classic graph combinatorial optimization models: Maximum Independent Set, Minimum Vertex Cover, and Max Cut. We apply TDP to enhance algorithms across diverse paradigms, including evolutionary search, greedy heuristics, and graph-neural-network-based heuristics. For all combinations of optimization models and base algorithms, TDP significantly improves performance over the original methods. In many settings, TDP-enhanced greedy heuristics are competitive with, and sometimes clearly outperform, state-of-the-art commercial solvers.

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