Ransomware is a fast-escalating privacy threat causing significant financial and data losses worldwide. As attacks grow more sophisticated, traditional static signatures and dynamic behavior analysis struggle to defend. In this paper, we propose an novel framework that couples software-level scanning with hardware-level microprocessor activity monitoring to achieve efficient ransomware detection and mitigation. The contributions are threefold: (1) we employ adversarial training to harden static analysis against obfuscation and leverage hardware-assisted monitoring for real-time detection; (2) we integrate neural architecture search (NAS) to automatically tailor models for stronger generalizability; and (3) We validate the proposed approach through extensive experiments, demonstrating substantially improved detection accuracy and reduced latency compared with existing methods. Moreover, it provides trace-level interpretability that explains the underlying decision process.

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