For Vertex Cover, a minimal blocking set of a graph $G$ is an inclusion-wise minimal vertex set contained in no minimum vertex cover of $G$. Bougeret et al. [SIDMA 2022] showed that, for all minor-closed graph classes $\mathcal{G}$, Vertex Cover has a polynomial kernel parameterized by the distance to $\mathcal{G}$ if and only if $\mathcal{G}$ has bounded minimal blocking sets. In this work, we explore how far this connection between minimal blocking sets and kernelization extends to $\mathcal{F}$-Minor Deletion parameterized by the deletion distance to $\mathcal{G}$. A minimal $\mathcal{F}$-blocking set of $G$ is a minimal vertex set not contained in any optimal $\mathcal{F}$-Minor Deletion solution of $G$. For connected families $\mathcal{F}$, we show that if some graph class $\mathcal{G}$ closed under disjoint union has unbounded minimal $\mathcal{F}$-blocking sets, then $\mathcal{F}$-Minor Deletion parameterized by the deletion distance to $\mathcal{G}$ has no polynomial kernel. This generalizes a result of Hols et al. [SIDMA 2022] for Vertex Cover. We then show that this criterion does not capture all kernelization lower bounds for $\mathcal{F}$-Minor Deletion, even for minor-closed graph classes. Motivated by the work of Dekker and Jansen [Discrete Appl. Math. 2024], we study the more general notion of extended $\mathcal{F}$-blocking sets and the kernelization lower bounds they yield. For every fixed integer $η\geq 1$, Pw-$η$ Deletion is the problem of deleting at most $k$ vertices to reduce the pathwidth to at most $η$. We show that it has no polynomial kernel parameterized by the distance to graphs with pathwidth at most $η+1$. Moreover, for connected families $\mathcal{F}$, we show that $\mathcal{F}$-Minor Deletion parameterized by the distance to graphs with pathwidth at most $\max_{F\in\mathcal{F}} pw(F)+1$ has no polynomial kernel.

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