The Birnbaum-Saunders (BS) distribution has become a widely used model for positive and asymmetric continuous data. Several extensions of the BS distribution have been proposed, including regression formulations that relate its parameters to covariates. In this paper, we introduce a new regression model for the Generalized Birnbaum-Saunders (GBS) distribution, an extension that has received limited attention in the literature despite offering a stronger physical interpretation. The proposed framework follows the structure of Generalized Additive Models for Location, Scale, and Shape (GAMLSS), allowing covariate effects to be incorporated into all three parameters of the distribution, thereby providing greater flexibility for modeling data. In particular, one of the model parameters has a direct interpretation as the median of the response variable, facilitating the interpretation of covariate effects on the conditional median. Parameter estimation is performed via maximum likelihood, and hypothesis tests are proposed based on the Wald test. The proposed regression model is implemented in R through the gamlss package, allowing access to a broad range of tools for model fitting, diagnostics, and assessment. Monte Carlo simulation studies are conducted to investigate the finite-sample performance of the maximum likelihood estimators. The results show that the estimators exhibit desirable properties, with bias decreasing and efficiency increasing as sample size grows. Additionally, the behavior of the Wald test is investigated, showing good performance for moderate to large sample sizes. Finally, two applications to real data illustrate the practical usefulness of the proposed GBS regression model, demonstrating that it is a flexible alternative for modeling positive and asymmetric data compared to the BS model

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