Indirectly encoded neural networks can assign different activation functions to individual nodes, but the right functions are rarely known in advance. When the available set contains only standard monotonic functions, problems like parity become unsolvable, yet an all-inclusive palette underperforms a curated one. How should evolution discover which functions to use? We address this as a meta-learning problem, designing 13 strategies (11 inspired by biological adaptation mechanisms, plus baseline and oracle controls) that modify the set of available activation functions during evolution. Each strategy translates a biological principle into an evolutionary operator: for example, circadian-inspired oscillatory gating cycles functions in and out of the palette on a fixed schedule, while immune-inspired Clonal Selection permanently protects functions that consistently correlate with fitness. We evaluate all strategies across more than 3,000 runs on parity and non-parity problems, first evolving the activation palette alone, then co-evolving a per-node aggregation palette on harder problems; an independent replication with new seeds confirms a stable high-reliability tier, with Circadian holding its top rank. Bio-inspired strategies match the solve rate of a tuned baseline but converge up to twice as fast, with Circadian halving total compute. Strategy rankings reverse across problem types, with no strategy dominating all domains. Strategy success is largely shaped by timescale compatibility: strategies whose characteristic timescale matches the evolutionary evaluation window consistently outperform those that operate too slowly. The practical guideline: match the mechanism's timescale to the evaluation budget. Rescaling the slowest strategy bypasses the oscillatory barrier entirely: all nine solutions solve parity with non-oscillatory activations paired with min or max aggregation.

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