Partial missingness is common in high-dimensional data, but most existing change-point procedures are developed for fully observed sequences. We introduce gMiss, a graph-based framework for testing and localizing a change in the observed-data distribution of a partially observed high-dimensional sequence. The method treats the observed values together with the missingness indicators as the object of inference, so the target alternative is a change in the induced observed data law. It is designed for general distributional changes and requires neither sparsity nor Gaussianity. When the augmented observations are independent, the full permutation test controls type I error in finite samples. The procedure combines graph scans based on elementwise imputation and distance imputation. The two scans capture complementary graph patterns. Simulation results indicate that gMiss maintains accurate null calibration across the MCAR and MAR designs considered, remains competitive under Gaussian location alternatives, and exhibits strong power and localization performance in many non-Gaussian location and scale settings. We further illustrate the practical utility of the method through an application to genomic copy-number data, where gMiss identifies additional candidate boundaries that are visually plausible in the raw heatmap.

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