Measures of functional dependence that characterize both independence and perfect dependence have attracted growing interest. Despite their appealing theoretical properties, existing rank- and graph-based estimators can suffer from substantial bias under general dependence, limiting their usefulness for statistical inference. Moreover, a systematic and practically accessible framework for mitigating such bias while achieving semiparametric efficiency remains largely unavailable. In this paper, we develop a general framework for efficient estimation of measures of functional dependence through sample-splitting and cross-fitting. Our approach enables systematic bias reduction and semiparametrically efficient inference, and thus offers a flexible and theoretically grounded alternative to existing rank- and graph-based methods.

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