Key-value (KV) cache memory management is the primary bottleneck limiting throughput and cost-efficiency in large-scale GPU inference serving. Current systems suffer from three compounding inefficiencies: (1) the absence of unified KV cache sizing across all attention architectures--particularly multi-head latent attention (MLA), which is unsupported in general-purpose frameworks, resulting in up to 57x memory over-provisioning; (2) confinement of KV cache to a single memory tier (GPU HBM) despite the availability of a rich hierarchy spanning CPU DRAM, CXL-attached memory, NVMe via GPUDirect Storage, RDMA fabric, and parallel filesystems; and (3) reactive eviction policies that discard reusable state, forcing redundant recomputation. We present a unified system addressing all three. Our architecture-variant-aware sizing engine computes exact memory requirements per attention type; the resulting batch size gain reaches 7.4x for the one MLA model we evaluate (DeepSeek-V3), while the three GQA models see 1.0x, 1.0x, and 0.7x, so the GQA benefit is fleet-wide unified sizing rather than larger per-model batches. A six-tier memory hierarchy extends effective KV cache capacity from 40 GB to over 38 TB per node while maintaining sub-millisecond time-to-first-token (TTFT) for hot entries. A Bayesian reuse predictor with Beta conjugate priors over 16 (block-type, transition-type) pairs drives EMA-scored head-granular eviction and RoPE-aware prefetching. Component-level validation on trace replay using ShareGPT, LMSYS-Chat-1M, and agentic workloads demonstrates 70-84% cache hit rates. Analytical projections combining validated component behavior with published hardware specifications indicate TTFT reductions of 1.4x to 2.1x, throughput improvements of 1.7x to 2.9x, and 47% cost reduction relative to published baselines; these cluster-scale projections are analytical and carry no error bars.

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