Combined unilateral and bilateral binary outcomes frequently arise in studies involving paired organs. The risk difference is a clinically interpretable measure for comparing treatment effects between groups. Existing confidence interval methods are primarily based on asymptotic normality and may fail to adequately reflect finite-sample distributional features, particularly skewness. To address this issue, we propose a distribution-based confidence interval derived from the probability distribution of the risk difference estimator and a modified MOVER procedure that accounts for intra-subject correlation. Their performances are compared with those of commonly used asymptotic methods through extensive simulation studies. Across a broad range of parameter settings, all methods exhibited satisfactory performance as sample size increased. The proposed distribution-based interval achieved coverage probabilities close to the nominal level with interval widths comparable to those of existing procedures. In small sample settings, it was able to capture skewness in the sampling distribution that was not reflected by methods relying on asymptotic normality. Analyses of two real-world datasets demonstrated the practical applicability of the competing methods and yielded consistent inferential conclusions. The proposed approach provides an alternative framework for interval estimation of the risk difference in studies involving combined unilateral and bilateral binary outcomes.

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