Existing multi-focus image fusion (MFIF) methods often fail to preserve the uncertain transition region and detect small focus areas within large defocused regions accurately. To address this issue, this study proposes a new small-area-aware MFIF algorithm for enhancing object detection capability. First, we enhance the pixel attributes within the small focus and boundary regions, which are subsequently combined with visual saliency detection to obtain the pre-fusion results used to discriminate the distribution of focused pixels. To accurately ensure pixel focus, we consider the source image as a combination of focused, defocused, and uncertain regions and propose a three-region segmentation strategy. Finally, we design an effective pixel selection rule to generate segmentation decision maps and obtain the final fusion results. Experiments demonstrated that the proposed method can accurately detect small and smooth focus areas while improving object detection performance, outperforming existing methods in both subjective and objective evaluations. The source code is available at https://github.com/ixilai/SAMF.

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