Unlike conventional communication services, 6G Integrated Sensing and Communication (ISAC) services require complete end-to-end sensing operations, from data collection to processing, result generation, and exposure. In this article, we propose SESO-ISAC, a service-aware end-to-end sensing orchestration framework that maps a sensing service request to a complete sensing configuration under the sensing execution context. Rather than treating sensing configuration decisions independently, SESO-ISAC captures their interdependence across the end-to-end sensing operation, evaluates candidate configurations according to the applicable QoS requirements, and re- evaluates the selected configuration as the sensing execution context changes. Through two representative case studies, we show that the preferred sensing configuration depends on the overall performance across the applicable QoS dimensions and can change during operation.

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