Network motifs and colored local interaction patterns provide a useful way to describe the structure of complex networks. Motivated by an inverse realization perspective, we study the problem of assigning colors to the vertices of a fixed graph so that its edges realize a prescribed multiset of colored pairwise interactions. This problem is formalized by the Matching-Match Puzzle, introduced by Iburi and Uehara. We investigate how its computational complexity depends on the number of colors and on the structure of the host graph. We first prove that Matching-Match is NP-complete with only two colors, even when no vertex is precolored and the graph has maximum degree three. We then focus on spiders. We show that the problem is W[1]-hard parameterized by the number of colors even on spiders with only the body precolored. In contrast, for spiders whose legs have length at most two, we give a fixed-parameter tractable algorithm parameterized by the number of colors, allowing arbitrary precoloring. Finally, we prove NP-completeness for spiders whose legs all have length exactly three when precoloring is allowed.

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