2-local qubit Hamiltonian simulation, a fundamental task in quantum computing, is widely applied in various applications. This paper presents QBX, the first quantum compiler designed for 2-local qubit Hamiltonian simulation on quantum chiplet architectures. Existing general-purpose quantum compilers for chiplet architectures target quantum programs at the gate level and miss optimizations requiring high-level semantics of Hamiltonian simulation. Conversely, existing domain-specific compilers for Hamiltonian simulation are designed for monolithic architectures, and their limited scalability and inability to adapt to the heterogeneity of chiplet architectures lead to sub-optimal circuit outputs. QBX implements a scalable hierarchical approach to reduce both the amount and distance of cross-chiplet communications. It integrates the highway mechanism, a chiplet-oriented solution for efficient long-range qubit communication, to diminish cross-chiplet interaction costs. Furthermore, QBX efficiently aggregates 2-local Pauli strings into multi-target controlled gates, harnessing highways for deep optimization. Our evaluations show that QBX markedly outperforms both general-purpose and domain-specific compilers in circuit depth and operation count, while scaling to much larger 2-local Hamiltonian simulations.

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