AI agents increasingly perform open-ended tasks in settings where their conclusions can guide consequential decisions. We provide evidence that AI agents draw different conclusions from identical numerical data when the substantive framing changes. We demonstrate this behavior in high-stakes domains in medicine, election forensics, and geopolitical forecasting by holding the evidence fixed while changing the scenario in which the evidence appears. Across twelve agent-domain comparisons, agents' conclusions are strongly influenced by their prior beliefs. They are more likely to reach an affirmative conclusion when it is framed around a proposition they already regard as likely, while the reverse holds when the framing conflicts with their prior. The framing also changes how some agents work: they search more extensively, choose different analytical specifications, and evaluate the same evidence differently. These results identify a particular risk of delegating decision-making to AI agents, as their decisions may depend on prior beliefs that are neither specified in the task nor visible in the decision record.

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