Artificial intelligence (AI) is transforming not only what information systems researchers design, but also how design research is conducted. Yet existing literature offers limited guidance for computational design science (CDS) when AI actively participates in problem formulation, resource construction, design search, evaluation, and knowledge abstraction. We develop AI for Computational Design Science (AI4CDS), a five-phase methodological framework in which AI expands problem and design search while researchers retain responsibility for domain grounding, admissibility, verification, and scientific judgment. Collaboration is governed by graduated trust, reversibility, auditability, and differentiated reproducibility. We instantiate AI4CDS through ChildRiskGuard, an interpretable artifact for detecting short-form videos inappropriate for children, while documenting AI interactions, rejected alternatives, corrections, and audit trails. The case translates audience-dependent safety and explanation faithfulness into three technical challenges and develops an artifact that separates generic from child-specific risk, represents distinct developmental-risk mechanisms, and makes concept-level explanations part of the predictive computation. ChildRiskGuard achieves an F1 score of 0.769, substantially outperforming direct application of a general-purpose content-safety model while remaining competitive with strong benchmarks. The primary contribution is AI4CDS as a responsible framework for AI-enabled CDS; ChildRiskGuard provides process and artifact evidence of how AI-expanded, researcher-governed design can generate and evaluate novel computational design knowledge.

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