We study the classical single-machine scheduling problem of minimizing the sum of completion times of jobs in a non-clairvoyant setting, where the processing time of each job remains unknown until its completion. This is a hard problem for which no constant competitive algorithm is possible. Inspired by robust optimization and learning-augmented algorithms, we introduce a novel robustness framework that leverages structural information provided by a classification model to overcome this limitation. Specifically, we assume that jobs are partitioned into classes and we have access to the confusion matrix of the classifier, whose entry $(k,\ell)$ indicates the number of jobs predicted to belong to class~$k$ but that actually belong to class~$\ell$. In this manner, we are able to characterize uncertainty as a set of permutations within each predicted class, rather than as a collection of discrete numerical scenarios, avoiding the computational difficulty of classical robust metrics, such as Min-Max and Min-Max Regret. In addition to these worst-case metrics, we also consider the expected objective over all scenarios. We first propose an optimal non-adaptive strategy that is oblivious with respect to all three robust criteria. We then investigate adaptive and randomized algorithms, showing that they can outperform the optimal non-adaptive strategy when the matrix exhibits particular structural properties.

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