The transition from stateless generative models in artificial intelligence to stateful, autonomous agents represents an architectural evolution that, while providing the capabilities of long-term planning and the automation of enterprise workflows, also represents the introduction of a new form of security threat, the Chronos Vulnerability. The Chronos Vulnerability represents the threat of memory-based attacks, including the Memory Injection Attack (MINJA) and the sleeper agent, in which the internal belief system of the autonomous agent is compromised, effectively decoupling the attack vector from the final catastrophic event. This study formalizes the threat model for persistence-based attacks and the threat of Dynamics Blindness in the context of the World of Workflows benchmark, demonstrating that traditional endpoint content filters are insufficient for the current stateful architecture. Consequently, this study synthesizes a defense-in-depth landscape, categorizing emerging frameworks such as diagnostic trajectory guardrails (AgentDoG), formal temporal verification (Agent-C), immunological memory consensus (A-MemGuard), and hardware-anchored trust via GPU-based Trusted Execution Environments (TEEs) and Zero-Trust memory architectures.

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