Existing Supervised Fine-Tuning paradigms, particularly Full Parameter Fine-Tuning are often plagued by parameter redundancy, inconsistent data quality, and catastrophic forgetting, which current methods typically address in isolation and lack a unified optimization signal to bridge data selection, parameter updates, and knowledge preservation. To address this, we propose Neuron-Guided Fine-Tuning (NGFT), a holistic framework that leverages neuron activation patterns as a universal proxy to unify the fine-tuning lifecycle. NGFT operates via three synergistic mechanisms: (1) Adaptive Task-Specific Neuron Selection, which identifies essential neurons in a single forward pass to concentrate updates and reduce redundancy; (2) Activation-Based Data Selection, which prioritizes information-dense samples that maximize contribution to key neurons; and (3) Neuron Activation Alignment, a novel loss function that anchors activations to pre-trained states, deepening representation learning and preserving general knowledge. Experimental results across three models across both domain-specific and general benchmarks demonstrate that NGFT significantly outperforms existing mainstream fine-tuning methods in both efficiency and performance, while effectively mitigating catastrophic forgetting.

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