Diffusion models have demonstrated remarkable effectiveness in image restoration tasks. However, when guiding image reconstruction, existing Diffusion Model-based Image Restoration (DMIR) methods typically rely on fixed data constraints and uniform step sizes, thereby overlooking the dynamic nature of the generative process. Such rigid designs render the models vulnerable to spatially non-uniform degradations, thus resulting in structural distortions and loss of fine details. Meanwhile, uniform step sizes introduce computational redundancy, whereas naïve step reduction strategies tend to accumulate approximation errors. To address these limitations, we propose a Local Epistemic Uncertainty Guided Active Sampling framework (LEADer). In the spatial domain, LEADer leverages pixel-wise uncertainty to dynamically modulate the prior strength within the null space, which effectively balances detail preservation and artifact suppression. In the temporal domain, it quantifies sampling stability via the uncertainty trace to enable adaptive trajectory pruning, thereby accelerating convergence. Theoretical proofs demonstrate that our framework achieves strict data consistency, while the trajectory pruning strategy admits a deterministic error bound, thereby guaranteeing stable convergence under skip sampling. Notably, our plug-and-play method can be seamlessly integrated into various DMIR baselines. Extensive experiments show that LEADer improves the performance of multiple state-of-the-art DMIR methods, while significantly reducing sampling time with negligible memory overhead. Code is available at https://github.com/JiaqiZhang-Sengoku/LEADer.

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