Long-horizon surgical assistance requires humanoid robots to coordinate with evolving human activities while maintaining safety across planning and execution. We present RoboAssist, an agent-based framework for interactive human-humanoid planning that integrates workflow reasoning, task coordination, and cross-layer safety. At its core is an asymmetric dual-track representation that separates partially observed human process states from executable robot task sequences. By updating human-process estimates, scene context, and task dependencies online, RoboAssist revalidates the remaining task sequence and replans only the affected suffix when workflow requests change. A cross-layer safety architecture combines preventive navigation regulation, reactive regulation during close-range handover, and independent whole-body runtime supervision. This design couples online task coordination with safety constraints throughout execution. We demonstrate the framework on a Unitree G1 humanoid robot in long-horizon, multi-stage simulated surgical assistance scenarios encompassing multimodal interaction, instrument handling, medical material transport, navigation, and safe human-robot handover. Experiments show multi-stage task completion and adaptation to workflow-request changes. A targeted full-replanning ablation shows that residual replanning reduces plan-update latency and post-update token usage. Separate safety experiments demonstrate complementary protection across navigation, handover, and runtime supervision. Additional results and demonstrations are available online at https://roboassist.github.io.

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