Many of our critical infrastructure systems and personal computing systems have a distributed computing systems structure. The incentives to attack them have been growing rapidly as has their attack surface due to increasing levels of connectedness. Therefore, we feel it is time to bring in rigorous reasoning to secure such systems. The distributed system security and the game theory technical communities can come together to effectively address this challenge. In this article, we lay out the foundations from each that we can build upon to achieve our goals. Next, we describe a set of research challenges for the community, organized into three categories -- analytical, systems, and integration challenges, each with "short term" time horizon (2-3 years) and "long term" (5-10 years) items. This article was conceived of through a community discussion at the 2022 NSF SaTC PI meeting.

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