Diffusion-based unsupervised domain adaptation (UDA) improves cross-domain transfer by generating target-specific synthetic data for downstream adaptation. Existing methods are largely designed for single-target adaptation: when a model trained on one labeled source domain must be adapted to multiple unlabeled target domains, they typically require separate diffusion fine-tuning for each source--target pair, causing training, storage, and deployment costs to grow with the number of targets. In this paper, we study multi-target data generation for diffusion-based UDA, where a single source-guided diffusion fine-tuning process is reused to generate target-specific synthetic data for multiple target domains. We propose MUSE (Multi-target UDA-oriented Synthesis with Efficient diffusion fine-tuning), a decoupled adaptation framework that separates source-supervised semantic adaptation from target-specific style adaptation. MUSE uses a shared semantic branch updated by labeled source data and target-private style branches specialized to individual target domains, enabling target-specific generation while avoiding repeated source-guided fine-tuning for each target. Experiments on standard UDA benchmarks show that MUSE achieves a stronger accuracy--efficiency trade-off than repeated per-target diffusion adaptation, reducing diffusion fine-tuning cost while improving average target-domain accuracy. The project page is available at https://xuanqi99.github.io/MUSE/.

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