Voice-assistant interruptions tend to be intrusive because existing systems fail to consider the affective state, cognitive load and situational context of the user when deciding when and how to interrupt.Voice-assistant interruptions tend to be intrusive, since existing systems do not consider the affective state, cognitive load or situational context of the user when determining when and how to interrupt. In this paper, EmpathicVA, a closed-loop framework integrating physiological sensing, vocal-affect analysis, contextual modeling and reinforcementlearning interruption policy, is introduced. A hierarchical fusion model involves integrating HRA, EDA, respiration, acousticprosodic features, linguistic embeddings, and contextual cues and computing the probabilities of five affective states. A Double Deep Q-Network selects immediate response, brief or extended delay, empathetic response, or silent mode based on these probabilities, context and interaction history. The multimodal model obtained an accuracy of 92.3% and an F1-score of 0.922 at the macro level on a held-out test set, outperforming the highest accuracy unimodal model by 6.0 percentage points. Comparing the six-week within-subject field study with 48 participants with a baseline and context-only assistants, there was a corresponding increase in satisfaction, trust, and appropriateness of timing, as well as a large reduction in interruption-related stress episodes. The results suggest that affect-aware timing and restraint are both important in voice interaction in addition to the response wording.

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