Studying brain function and dysfunction in spiking networks with realistic synaptic densities pushes simulation technology beyond its current limits. It requires simulations substantially faster than biological real-time to cover long model times and enable efficient iterative exploration, particularly when connectivity is plastic. The modelling community aspires to a $100\times$ speedup. Yet on conventional many-core systems this remains elusive, bounded by inter-node communication and memory access. So far, significant speedup has only been shown on a custom-built FPGA system. We demonstrate the potential of commercial systems with large distributed on-chip memory to accelerate brain research. To exploit the local SRAM, we introduce a group-based mapping and communication strategy tackling spike-routing challenges on massively distributed systems. On Graphcore IPUs, the cortical microcircuit runs at a record $22.7\times$ faster than biological real-time with negligible build times and a reusable compiled graph. By design, the algorithm makes no model- or hardware-specific assumptions, providing a general strategy for advancing neuronal simulation technology.

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