As Alzheimer's disease (AD) has increasingly become a major global public health issue, speech-based AD detection has attracted widespread attention. However, most existing methods are trained and evaluated on a single dataset, often leading to severe cross-domain performance degradation due to reliance on dataset-specific artifacts rather than disease-related speech cues. In real-world applications, reliable Alzheimer's disease detection requires models that are robust to variations in recording environments, speakers and data collection conditions. To address this challenge, this paper adopts unsupervised domain adaptation to learn robust, domain-invariant feature representations in the absence of target-domain diagnosis labels. On this basis, a novel unsupervised domain adaptation method, Iterative Adversarial Self-Training (IAST), is proposed. Results demonstrate that IAST significantly improves the generalization ability and robustness under various cross-domain settings.

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