Background: Accurate body composition analysis using Computed Tomography (CT) scans is essential for assessing skeletal muscle area (SMA) and skeletal muscle density (SMD), key markers of nutritional status in cancer patients. Conventional manual methods are labour-intensive and require specialist expertise, limiting their routine clinical use. Therefore, this study serves as a feasibility and pilot investigation to explore the potential of deep learning-based automated regression for body composition analysis within a clinical workflow. Methods: Four deep learning architectures (AlexNet, UNet, GoogLeNet, and ResNet34) were trained to predict SMA, SMD, subcutaneous fat area (SFA), and visceral fat area (VFA) from CT scans of colorectal cancer patients. Systematic hyperparameter optimization identified the most accurate models, which were subsequently implemented in a web application for clinical use. Results: GoogLeNet achieved the best performance, with a mean percentage error (PE) of 4.96% for SMA prediction, while AlexNet reached 8.12% for SMD. Independent testing demonstrated robust accuracy, correctly classifying body composition metrics in 80% of cases. The web application delivered rapid and consistent outputs, supporting integration into clinical workflows. Conclusion: Optimized deep learning models, particularly GoogLeNet and AlexNet, can automate CT-derived body composition analysis with a Mean Percentage Error (PE) of 4.96% for SMA and 8.12% for SMD. These tools have the potential to streamline clinical practice by reducing the time and expertise required for manual segmentation. Further validation in larger, more diverse datasets is warranted.

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