Statistical inference in sequential mediation models requires evaluating the cumulative distribution function (CDF) of the product of three normal coefficient estimators, an operation that entails integrating over a non-convex region with boundary $xyz=v$. While the Delta method provides an instantaneous first-order approximation, its asymptotic variance collapses whenever two or more path coefficients approach zero, producing severe undercoverage near parameter boundaries. Nonparametric bootstrapping avoids gradient collapse but incurs an $O(B \times N)$ computational cost that becomes burdensome in large-scale simulation studies or iterative power analyses. We propose a model-based dimension-reduction algorithm that integrates out the third variable analytically under the trivariate Gaussian distribution for arbitrary mean vectors and positive-definite covariance matrices. Partitioning the $xy$-plane into quadrants isolates the sign change at the coordinate axes, reducing the problem to an adaptive two-dimensional quadrature whose fixed-grid cost is $O(n^2)$ in place of $O(n^3)$. In simulation benchmarks across six parameter regimes, the algorithm achieves a mean absolute error of $3.1 \times 10^{-5}$ relative to a $10^{8}$-sample Monte Carlo reference, evaluating the distribution in under one second and yielding plug-in quantile confidence intervals whose empirical coverage was near or above nominal.

翻译：暂无翻译