Recently, we have witnessed the success of total variation (TV) for many imaging applications. However, traditional TV is defined on the original pixel domain, which limits its potential. In this work, we suggest a new TV regularization defined on the neural domain. Concretely, the discrete data is continuously and implicitly represented by a deep neural network (DNN), and we use the derivatives of DNN outputs w.r.t. input coordinates to capture local correlations of data. As compared with classical TV on the original domain, the proposed TV on the neural domain (termed NeurTV) enjoys two advantages. First, NeurTV is not limited to meshgrid but is suitable for both meshgrid and non-meshgrid data. Second, NeurTV can more exactly capture local correlations across data for any direction and any order of derivatives attributed to the implicit and continuous nature of neural domain. We theoretically reinterpret NeurTV under the variational approximation framework, which allows us to build the connection between classical TV and NeurTV and inspires us to develop variants (e.g., NeurTV with arbitrary resolution and space-variant NeurTV). Extensive numerical experiments with meshgrid data (e.g., color and hyperspectral images) and non-meshgrid data (e.g., point clouds and spatial transcriptomics) showcase the effectiveness of the proposed methods.

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