Epilepsy is a neurological illness that is characterised by continuous spasms of shaking, sometimes known as convulsions. Although there are effective treatments for epilepsy, such as drugs and surgery, there is still a group of individuals who have intractable epilepsy that fails to respond to standard methods. Intractable epilepsy is a severe neurological illness that ripples across the globe and impacts millions of individuals. It is extremely difficult to control intractable epilepsy, which is defined as the lack of response to two or more standard antiepileptic medication treatments. In recent years, the use of programmable electrical stimulation of the brain has shown promise as a digital treatment strategy for lowering seizure frequency in individuals with intractable epilepsy. In this research, the use of Amenable Neurostimulation (ANS) as part of a digital treatment strategy to intractable epilepsy is investigated. When applied to the brain, ANS uses a closed-loop system to selectively stimulate neurons in the affected areas, therefore lowering the frequency of seizures. In addition, the report describes the design and execution of a pilot research employing ANS to treat intractable epilepsy, including patient selection criteria, device settings, and outcome measures. The findings of this pilot research point to the possibility that ANS might be a realistic and successful therapy option for people afflicted with intractable epilepsy. This paper demonstrated the prospects of digital medicines in treating complicated neurological illnesses and recommends future routes for research and development in this field.

翻译：癫痫是一种以持续性痉挛（常称为惊厥）为特征的神经系统疾病。尽管存在有效的治疗方法（如药物和手术），仍有一部分患者患有对传统疗法无反应的难治性癫痫。难治性癫痫是一种严重的神经系统疾病，波及全球并影响数百万患者。其定义为对两种及以上标准抗癫痫药物治疗缺乏反应，因此极难控制。近年来，使用可编程脑电刺激作为数字治疗策略，在降低难治性癫痫患者癫痫发作频率方面展现出潜力。本研究探讨了适应性神经刺激（ANS）作为数字治疗策略的一部分应用于难治性癫痫的可行性。ANS采用闭环系统选择性地刺激大脑受影响区域的神经元，从而降低癫痫发作频率。此外，本文还描述了一项采用ANS治疗难治性癫痫的初步研究的设计与实施，包括患者选择标准、设备参数设置及结果评估指标。该初步研究结果表明，ANS可能成为难治性癫痫患者的一种可行且有效的治疗选择。本论文展示了数字药物在治疗复杂神经系统疾病中的前景，并指出了该领域未来研究与发展的方向。