Rapid intensification (RI) remains one of the most consequential and difficult aspects of tropical cyclone (TC) forecasting. Although full-physics numerical weather prediction models can represent the processes governing RI, resolving storm-environment interactions remains computationally expensive, while purely data-driven approaches often lack physical interpretability. We present FAST-ML, a hybrid framework that bridges data-driven efficiency with physical constraints. A physically informed dual-stream neural parameterization ingests 3D ERA5 fields to diagnose ventilation controls---environmental wind shear and mid-level entropy deficit. By optimizing these parameters end-to-end through a differentiable FAST intensity model, this architecture establishes a robust new paradigm for observation-driven parameter optimization, ensuring storm evolution remains strictly governed by thermodynamic principles. By better capturing the storm's continuous intensity evolution, FAST-ML improves upon its physical baseline, reducing ensemble CRPS across forecast lead times, with a reduction of approximately 31% at 60 h and nearly halving the RI false alarm ratio without sacrificing detection skill. In a 100-member ensemble configuration, FAST-ML produces intensity forecasts comparable to FNV3 for selected storms under the evaluated input configurations. Furthermore, zero-shot tests on selected Eastern Pacific storms provide encouraging evidence of cross-basin transferability. FAST-ML provides a modular intensity forecasting framework that can be coupled with externally supplied storm tracks and environmental fields. It demonstrates that observation-driven parameter learning within physically constrained dynamics simultaneously enhances accuracy, interpretability, and computational efficiency.

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