The pharmaceutical supply chain faces escalating cybersecurity challenges threatening patient safety and operational continuity. This paper examines the transformative potential of zero trust architecture for enhancing security and resilience within this critical ecosystem. We explore the challenges posed by data breaches, counterfeiting, and disruptions and introduce the principles of continuous verification, least-privilege access, and data-centric security inherent in zero trust. Real-world case studies illustrate successful implementations. Benefits include heightened security, data protection, and adaptable resilience. As recognized by researchers and industrialists, a reliable drug tracing system is crucial for ensuring drug safety throughout the pharmaceutical production process. One of the most pivotal domains within the pharmaceutical industry and its associated supply chains where zero trust can be effectively implemented is in the management of narcotics, high-health-risk drugs, and abusable substances. By embracing zero trust, the pharmaceutical industry fortifies its supply chain against constantly changing cyber threats, ensuring the trustworthiness of critical medical operations.

翻译：药品供应链面临着日益严峻的网络安全挑战，威胁患者安全与运营连续性。本文探讨了零信任架构在提升这一关键生态系统安全性与韧性方面的变革潜力。我们分析了数据泄露、伪造药品和供应链中断所带来的挑战，并阐述了零信任所固有的持续验证、最小权限访问和数据中心安全原则。通过实际案例研究展示了成功实施的经验。其优势包括更高的安全性、数据保护以及适应性韧性。研究人员和业界人士均认识到，一个可靠的药品追溯系统对于确保药品生产全过程中的药物安全至关重要。在制药行业及其相关供应链中，零信任可有效实施的最关键领域之一在于麻醉药品、高风险健康药物及易滥用物质的管理。通过采纳零信任，制药行业强化了其供应链以应对不断变化的网络威胁，确保了关键医疗运营的可信度。