项目名称： 基于酰腙多重刺激响应动态共价聚合物材料的设计合成、组装及分子识别研究

项目编号： No.21504094

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 查代君

作者单位： 中国科学院福建物质结构研究所

项目金额： 20万元

中文摘要： 动态共价键由于其可逆与可修复性常被用来构建智能响应材料，在药物传递、化学传感、分子机器等领域具有重要的应用前景。然而目前文献报道的体系大都只具有单一刺激响应性，研发具有多重刺激响应的动态智能材料尤为迫切。本项目拟以含多种分子识别位点的动态酰腙键为平台，构建新型具有多重刺激响应的动态共价聚合物材料，并研究其在分子识别中的应用。首先，设计合成并筛选出1-2种可用于金属离子识别的多重刺激响应酰腙动态共价聚合物；在此基础上探究金属离子/阴离子对该类聚合物的协同作用，实现水相中阴离子的识别；为进一步提高智能响应材料的结构和功能多样性，拟将酰腙与1,2,3-三唑结合，合成一类两亲性的超支化动态共价聚合物，并制备具有多重刺激响的金属动态共价聚合物凝胶。预期本项目研究成果将为未来功能材料组装和调控以及分子识别和传感等研究奠定坚实的基础。

中文关键词： 酰腙；动态共价聚合物；自组装；协同作用；分子识别

英文摘要： Due to their reversible and repairable properties, the dynamic covalent bonds are often used to build smart responsive materials which possess great application potential in the fields of drug delivery, chemical sensing, and molecular machines. However, most dynamic covalent materials reported in the literatures are restricted by their single responsiveness. As a result, it is of great significance to develop dynamic covalent systems with multi-responsiveness. The goal of this project is to construct novel dynamic covalent polymers with multi-responsiveness by combining the acylhydrazone bonds with multiple molecular recognition sites and to explore the applications of these materials in molecular recognition and sensing. Firstly, a series of dynamic covalent polymers will be prepared, characterized, and modulated by multiple stimuli, and their assembly with metal ions will be explored as a means of sensing these ions. Based on these results, cooperative binding of both cations and anions will be examined for the purpose of detecting anions in water. To further enhance the structure and functional diversity of intelligent polymer materials, 1, 2, 3-triazole will be incorporated into the dynamic acylhydrazone polymer backbones to create a class of novel amphiphilic hyperbranched polymers which form gels in the presence of external stimuli, such as metal ions. The results of this project will lay a solid foundation for the research of assembly and modulation of functional materials as well as molecular recognition and sensing in the future.

英文关键词： Acylhydrazone;Dynamic Covalent Polymers ;Self-assembly;Cooperative Interaction;Molecular Recognition